Heterocycle-fused lupane triterpenoids inhibit Leishmania donovani amastigotes
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چکیده
منابع مشابه
Elimination of Leishmania donovani amastigotes by activated macrophages.
Tissue macrophages are the obligatory host cells for Leishmania donovani, the causative agent of visceral leishmaniasis. In this study we sought to determine whether activated macrophages, as defined by the functional criterion of tumor cell cytotoxicity, were also able to exert a microbicidal effect on ingested L. donovani amastigotes. We found that mouse peritoneal macrophages activated by a ...
متن کاملCytotoxicity of human serum for Leishmania donovani amastigotes: antibody facilitation of alternate complement pathway-mediated killing.
Mechanisms that mediate recovery from leishmanial infection have not been fully characterized but are generally believed to involve interactions between T lymphocytes and macrophages. A major role for serum-mediated effector mechanisms in the protection of humans from reinfection with Leishmania, however, has not been ruled out. In this report, amastigotes of L. donovani were incubated with dil...
متن کاملStage-specific activity of pentavalent antimony against Leishmania donovani axenic amastigotes.
The standard treatment of human visceral leishmaniasis involves the use of pentavalent antimony (SbV) compounds. In recent years increasing numbers of clinical failures of treatment with SbV have been reported, probably due to the development of parasite resistance to this compound. The mode of action and mechanisms of resistance to SbV have not been fully elucidated. In the present study an ax...
متن کاملArginase Is Essential for Survival of Leishmania donovani Promastigotes but Not Intracellular Amastigotes
Studies of Leishmania donovani have shown that both ornithine decarboxylase and spermidine synthase, two enzymes of the polyamine biosynthetic pathway, are critical for promastigote proliferation and required for maximum infection in mice. However, the importance of arginase (ARG), the first enzyme of the polyamine pathway in Leishmania, has not been analyzed in L. donovani To test ARG function...
متن کاملCharacterization of plasma membrane bound inorganic pyrophosphatase from Leishmania donovani promastigotes and amastigotes.
BACKGROUND Currently, a major problem in the management of visceral leishmaniasis or kala-azar, especially in the Indian subcontinent, is the growing unresponsiveness to conventional antimonial therapy. Membrane bound pyrophophatase (PPases) do not exist in plasma membrane from mammals. Thus, H(+)-PPases from Leishmania plasma membrane might be potential target in rational chemotherapy of the d...
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ژورنال
عنوان ژورنال: Med. Chem. Commun.
سال: 2014
ISSN: 2040-2503,2040-2511
DOI: 10.1039/c3md00282a